One of my labmates’ father’s colleagues won the Nobel Prize in Physiology or Medicine this morning. Apparently they had shared offices or something like that.
Anyway this year’s prize is for way cool research on knockout mice. Capecchi, Evans and Smithies invented the procedure to carefully prepare genetic mutations in mouse embryonic stem cells. When injected into mice, the artificial genes inserted into the stem cells inactivate, or ‘knock out’, those already in the mouse, thus effecting the desired phenotypes in aforementioned mice.
Knockout mice have been used to study the genetic factors responsible for a wide variety of ailments, such as Parkinson’s disease and obesity:

The department has been abuzz over who will win tomorrow’s physics prize and Wednesday’s chemistry prize. Chembark even has betting odds for the chemistry one. Oddly enough, Yamamoto Mayu’s chemical process to make vanilla flavoring from cow dung, winner of the 2007 Ig Nobel Prize1 in chemistry and now of Toscanini’s Yum-a-Moto Vanilla Twist fame, didn’t make their list.
Footnotes- Other hysterical winners: the US Air Force “gay bomb”, a chemical spray designed to disrupt the discipline of enemy troops by making them horny for each other (Peace); a study of hamster circadian rhythms that showed that Viagra helped hamsters beat jet lag (Aviation); and a study that showed that swallowing swords can tear your esophagus (Medicine). ↩




